Improving motor function in ALS using spinal cord stimulation techniques
Spinal Cord Associative Plasticity for Amyotrophic Lateral Sclerosis
This study is looking at how two types of stimulation, one on the spinal cord and one on the brain, can help improve movement and muscle control for veterans with ALS by encouraging the nervous system to heal and work better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James J Peters VA Medical Center NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11053339 on NIH RePORTER |
What this research studies
This research investigates the use of transcutaneous spinal cord stimulation (TSCS) combined with transcranial magnetic stimulation (TMS) to enhance motor function in patients with amyotrophic lateral sclerosis (ALS). By applying these stimulation techniques, the study aims to activate damaged neural circuits in the spinal cord, potentially improving muscle control and overall motor function. The approach focuses on increasing neural plasticity, which may help strengthen voluntary motor output and prepare weakened circuits for better responses to exercise. The research is particularly relevant for veterans, as ALS is more prevalent in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis, particularly veterans.
Not a fit: Patients with advanced stages of ALS or those who do not respond to neuromodulation therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved motor function and quality of life for patients with ALS.
How similar studies have performed: Previous studies have shown promising results with similar neuromodulation techniques in spinal cord injury, suggesting potential for success in ALS.
Where this research is happening
Bronx, United States
- James J Peters VA Medical Center — Bronx, United States (Active)
Researchers
- Principal investigator: Harel, Noam Y. — James J Peters VA Medical Center
- Study coordinator: Harel, Noam Y.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.