NIH-funded research NIH-funded research

Improving motor function in ALS using spinal cord stimulation techniques

Official title: Spinal Cord Associative Plasticity for Amyotrophic Lateral Sclerosis

Funded at James J Peters VA Medical Center · NIH-11053339 · Data updated 2026-11-12

This study is looking at how two types of stimulation, one on the spinal cord and one on the brain, can help improve movement and muscle control for veterans with ALS by encouraging the nervous system to heal and work better.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionJames J Peters VA Medical Center
NIH-funded
Lab location1 site (Bronx, United States)
Project startApril 1, 2024
Project endMarch 31, 2028
Funding year2025
NIH project number5I01RX004258-02
Project IDNIH-11053339 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis, particularly veterans.

Less likely to help

Patients with advanced stages of ALS or those who do not respond to neuromodulation therapies may not benefit from this research.

What this research studies

This research investigates the use of transcutaneous spinal cord stimulation (TSCS) combined with transcranial magnetic stimulation (TMS) to enhance motor function in patients with amyotrophic lateral sclerosis (ALS). By applying these stimulation techniques, the study aims to activate damaged neural circuits in the spinal cord, potentially improving muscle control and overall motor function. The approach focuses on increasing neural plasticity, which may help strengthen voluntary motor output and prepare weakened circuits for better responses to exercise. The research is particularly relevant for veterans, as ALS is more prevalent in this population.

Why it matters

Potential benefit: If successful, this research could lead to improved motor function and quality of life for patients with ALS.

How similar studies have gone: Previous studies have shown promising results with similar neuromodulation techniques in spinal cord injury, suggesting potential for success in ALS.

Where this research is happening

  • James J Peters VA Medical Center
    Bronx, United States
    Active

Researchers

  • Principal investigator: Harel, Noam Y. — James J Peters VA Medical Center
  • Study coordinator: Harel, Noam Y.

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.