Improving methods for analyzing long-read cancer genome sequencing
Official title: Enhancement and further development of informatics methods for long-read cancer sequencing
Funded at Dana-Farber Cancer Inst · NIH-10990145 · Data updated 2026-11-12
This study is working on improving the ways we analyze genetic information from cancer to help doctors find changes in genes more accurately, and it will also create a helpful database of this information for future research.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $872,555 |
| NIH project number | 1U24CA294203-01 |
| Project ID | NIH-10990145 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with various types of cancer, particularly those with genetic alterations related to BRCA1 and BRCA2 genes.
✕Less likely to help
Patients without a cancer diagnosis or those whose cancer is not associated with genetic alterations may not benefit from this research.
What this research studies
This research focuses on enhancing the tools and techniques used to analyze long-read sequencing data from cancer genomes. By developing better algorithms and bioinformatics methods, the project aims to improve the accuracy of detecting genetic alterations associated with cancer. Additionally, the researchers will create a comprehensive database of long-read cancer genome data to benchmark these new methods. This work is expected to advance our understanding of cancer genetics and improve diagnostic capabilities.
Why it matters
Potential benefit: If successful, this research could lead to more accurate cancer diagnoses and personalized treatment options for patients.
How similar studies have gone: Previous research has shown promise in using long-read sequencing for cancer genomics, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Li, Heng — Dana-Farber Cancer Inst
- Study coordinator: Li, Heng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.