Comparative Modeling to Prevent, Detect Early, and Treat Multiple Myeloma
Official title: Comparative Modeling of Multiple Myeloma Prevention, Early Detection and Treatment Interventions
Funded at Washington University · NIH-11495288 · Data updated 2026-11-12
A research team will build and compare computer models to understand how multiple myeloma develops, can be detected earlier, and treated more effectively.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 18, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $848,978 |
| NIH project number | 1U01CA319115-01 |
| Project ID | NIH-11495288 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or at risk for multiple myeloma or its precursor conditions (e.g., MGUS, smoldering MM) could potentially benefit from improved screening and treatment planning informed by the models.
✕Less likely to help
The study itself does not enroll patients; individuals will not receive a direct intervention as part of this modeling effort.
What this research studies
This project uses computational models to map how multiple myeloma and its precursor conditions progress over time. By comparing different modeling approaches and scenarios, it aims to identify strategies that could prevent progression and improve management. The work will focus on population-level patterns, treatment pathways, and policy-relevant questions that could inform future patient care. The findings may help shape how we monitor high-risk individuals and optimize treatment regimens, with aim toward better outcomes for people affected by this cancer.
Why it matters
Potential benefit: If successful, the work could lead to earlier detection and more cost-effective, personalized management strategies for multiple myeloma.
How similar studies have gone: Modeling efforts like CISNET have influenced policy and practice in solid tumors; this project extends similar methods to multiple myeloma with promising potential for impact.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Chang, Su-Hsin — Washington University
- Study coordinator: Chang, Su-Hsin
Related research
Other NIH-funded projects on the same topics.
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Integrative study of multiple myeloma genetics and disease biology
A team at Dana-Farber and partners is pursuing a long-term project to understand the genetic and molecular drivers of multiple myeloma and how treatments interact with disease biology.
-
How LDL Affects Multiple Myeloma: New Pathways to Keep Remission
A new grant is studying how cholesterol from LDL particles fuels multiple myeloma and how this interaction influences the tumor environment and immune response, with goals to help patients stay in remission.
-
Therapy-induced senescence and immune activation in multiple myeloma
A study in people with multiple myeloma will explore how treatment-related senescence in cancer cells may stimulate the immune system and affect cancer return after standard frontline therapy.
-
BCMA CAR-T enteritis: understanding immune toxicities in multiple myeloma
A broad study to uncover why some CAR-T cell treatments targeting BCMA cause severe intestinal inflammation in people with multiple myeloma.
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Understanding Drug-Resistant Multiple Myeloma to Stop Relapse
Researchers are studying why some myeloma cells resist treatment and how to create new therapies to prevent relapse.
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Overcoming resistance to CART cell therapy in multiple myeloma
This grant aims to improve CAR T-cell therapy for people with multiple myeloma by tackling why some patients stop responding, using innovative approaches to boost cancer-fighting cells in the bone marrow.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.