Improving how liquid biopsy samples are processed and stored for cancer testing.
Official title: Guidelines for processing and storing liquid biopsy samples for functional assays in research and clinical testing.
Funded at Oregon Health & Science University · NIH-10862478 · Data updated 2026-11-12
This study is looking at the best ways to collect and store blood and bone marrow samples from leukemia patients to make sure tests for cancer treatment are as accurate as possible, helping doctors provide better care for people with acute myeloid leukemia and other cancers.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | September 23, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $356,850 |
| NIH project number | 1U01CA288669-01 |
| Project ID | NIH-10862478 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with acute myeloid leukemia (AML) or other related blood cancers.
✕Less likely to help
Patients with solid tumors or those not undergoing liquid biopsy testing may not benefit from this research.
What this research studies
This research focuses on establishing standardized guidelines for processing and storing liquid biopsy samples, such as blood and bone marrow, which are essential for functional assays in cancer diagnosis and treatment. By analyzing samples from over 2,500 leukemia patients, the project aims to identify how different pre-analytical factors affect the reliability of test results. The goal is to enhance the accuracy of precision medicine approaches in treating acute myeloid leukemia (AML) and other cancers. This work will involve collaboration across various institutions to ensure consistent practices in sample handling.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and reliable cancer diagnostics, ultimately improving treatment outcomes for patients.
How similar studies have gone: Previous research has shown that standardizing sample processing can significantly improve the reliability of diagnostic tests, indicating a promising approach in this area.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Vu, Tothu Q — Oregon Health & Science University
- Study coordinator: Vu, Tothu Q
Related research
Other NIH-funded projects on the same topics.
-
Towards a blood-based test using nanophotonic exosomes to screen and diagnose liver cancer
A new blood test using tiny particles shed by liver cancer cells aims to screen for hepatocellular carcinoma earlier and more accurately.
-
Liquid biopsy test to screen for lymphoma in people with HIV
A new blood test called High Density Methyl-Seq is being checked to see if it can detect lymphoma early in people living with HIV.
-
Liquid biopsy and oxygen therapy to guide glioblastoma treatment
A patient-focused study exploring a blood-based test and a safe oxygen therapy to help doctors tell true tumor growth from treatment effects in adults with glioblastoma treated with chemoradiation.
-
Liquid biopsy to monitor LMS treatment and resistance
A patient-centered look at using blood tests to see how well LMS treatment is working and when resistance to therapy appears.
-
Imagnostix: a simple blood-based test to flag Alzheimer’s risk
A new blood-based test called Imagnostix aims to help identify people who may be developing Alzheimer’s disease earlier and more cheaply than current methods.
-
Multi-omic liquid biopsy to guide immunotherapy in colorectal and anal cancers
A patient-facing overview of a study testing blood-based biomarkers (ctDNA and extracellular RNA) to better tailor immunotherapy for colorectal and anal cancer patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.