Improving heart valve replacement by lacerating old leaflets
Official title: Simple and Effective Laceration of Potentially-calcified Leaflets as an Adjunct to Transcatheter Valve Replacement
Funded at Boston Children's Hospital · NIH-11012915 · Data updated 2026-11-12
This study is looking at a new way to replace heart valves that might help patients who can't have regular surgery by making small cuts in the old valve to make room for a new one, which could lead to fewer problems and better results for those with heart valve issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 20, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $718,215 |
| NIH project number | 5R01HL167925-02 |
| Project ID | NIH-11012915 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with valvular heart disease who are at high risk for traditional surgery.
✕Less likely to help
Patients with non-calcified leaflets or those who are not candidates for any form of valve replacement will likely not benefit from this research.
What this research studies
This research investigates a new technique for heart valve replacement that involves lacerating potentially calcified leaflets before inserting a new valve. By cutting the old leaflets, the new valve can be positioned more effectively, reducing the risk of complications such as obstructed blood flow. This approach aims to make transcatheter valve replacement safer and more effective for patients who are too ill for traditional surgery. The study will evaluate the outcomes of this technique in patients with valvular heart disease.
Why it matters
Potential benefit: If successful, this research could enable more patients to safely undergo heart valve replacement procedures, improving their quality of life.
How similar studies have gone: Other research has shown promising results with similar techniques in improving outcomes for heart valve replacement, suggesting this approach may be effective.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Dupont, Pierre E — Boston Children's Hospital
- Study coordinator: Dupont, Pierre E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.