Improving cognitive function in patients with treatment-resistant schizophrenia using clozapine.
Accelerated Neuromodulation of Prefrontal Circuitry during Clozapine Treatment
This study is looking at how clozapine can help improve thinking skills, especially working memory, in people with schizophrenia who haven't responded to other treatments, and it will use special brain techniques to see how different parts of the brain work together to boost these skills.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10726660 on NIH RePORTER |
What this research studies
This research investigates how clozapine treatment can enhance cognitive function, particularly working memory, in individuals with treatment-resistant schizophrenia. It aims to explore the relationship between brain circuitry and cognitive performance, utilizing advanced techniques like transcranial magnetic stimulation to potentially accelerate improvements. By focusing on the dorsolateral prefrontal cortex and its connectivity with other brain regions, the study seeks to develop new strategies to address cognitive deficits that persist even after clozapine treatment. Patients may be monitored over time to assess changes in cognitive abilities and overall functioning.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with treatment-resistant schizophrenia who are currently receiving or have received clozapine treatment.
Not a fit: Patients with schizophrenia who do not meet the criteria for treatment resistance or those not on clozapine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive function and better daily functioning for patients with treatment-resistant schizophrenia.
How similar studies have performed: Previous research has shown promise in using transcranial magnetic stimulation to enhance cognitive function in related conditions, suggesting potential for success in this approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Sarpal, Deepak K — University of Pittsburgh at Pittsburgh
- Study coordinator: Sarpal, Deepak K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.