Improving breathing function after spinal cord injuries using electrical stimulation
Closed-loop epidural stimulation: respiratory motor plasticity and neural underpinnings
This study is looking at how a special type of electrical stimulation to the spinal cord can help people with cervical spinal cord injuries breathe better, which might even lessen their need for breathing machines.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11070430 on NIH RePORTER |
What this research studies
This research investigates how closed-loop electrical stimulation of the spinal cord can enhance breathing capacity in patients with cervical spinal cord injuries. By applying sub-threshold electrical currents, the study aims to stimulate the phrenic motor network, which is crucial for respiratory function. The approach focuses on understanding the conditions that maximize the benefits of this stimulation and the underlying mechanisms involved. Patients may experience improved respiratory function both during and after the stimulation treatment, potentially reducing their reliance on mechanical ventilation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have sustained cervical spinal cord injuries and experience breathing dysfunction.
Not a fit: Patients with spinal cord injuries at levels other than cervical or those without respiratory dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life for patients with cervical spinal cord injuries by enhancing their ability to breathe independently.
How similar studies have performed: Previous studies have shown promising results with similar electrical stimulation techniques in animal models, indicating potential for success in human applications.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Mickle, Alyssa Richelle — University of Florida
- Study coordinator: Mickle, Alyssa Richelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.