Improving Brain Health in MCI with Computerized Training That Supports Acetylcholine

Who could benefit from this research

What this research studies

This project will test a computerized cognitive training program called INHANCE-MCI in people with mild cognitive impairment. Participants will be randomly assigned to the training or an active comparison and will undergo assessments of brain chemistry, thinking skills, and everyday functioning. The study builds on prior SBIR and R44 work to combine two validated exercises that may work together to support cholinergic function. By understanding how brain training affects cognition and daily abilities, the project seeks practical strategies to delay dementia onset and improve quality of life. If successful, the program could become more widely available to individuals at risk for Alzheimer’s-related cognitive decline.

Why it matters

Where this research is happening

• Posit Science Corporation
  San Francisco, United States Active

Researchers

• Principal investigator: Attarha, Mouna — Posit Science Corporation
• Study coordinator: Attarha, Mouna

Related research

Other NIH-funded projects on the same topics.

• Improving Neurological Health with Brain Training for Mild Cognitive Impairment (INHANCE-MCI)

  A computer-based brain training program is being tested to help people with mild cognitive impairment maintain thinking skills and daily functioning.

  NIH research Posit Science Corporation · San Francisco, United States · NIH-11626504

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  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11494175

• Music-based program to support thinking and mood for adults 65+ at risk for Alzheimer's

  A clinical trial tests a six-week, hands-on music creativity program to help people 65 and older with mild cognitive impairment feel mentally sharper and happier.

  NIH research Rice University · Houston, United States · NIH-11450606

• Postsurgical pain and opioid use in older adults with mild cognitive impairment

  This grant studies how mild cognitive impairment in older adults affects pain after surgery and how opioids are used, with the goal of improving safer, better pain management.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11449194

• Molecular imaging of cholinergic signals and brain pathology in early Alzheimer’s

  This project uses brain imaging to study how the cholinergic system and Alzheimer’s pathology unfold in people at risk for dementia.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11447190

• Can patterns of spoken words in older adults help predict a memory condition

  This project looks at whether how older adults use and understand words can flag people who might develop amnestic mild cognitive impairment later on.

  NIH research Georgetown University · Washington, United States · NIH-11446796

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.