Immune complex signals steering neutrophils into powerful antigen-presenting cells in autoimmune kidney disease
Official title: Regulators of immune complex mediated neutrophil antigen presentation
Funded at University of Rochester · NIH-11473498 · Data updated 2026-11-12
This project looks at how immune system problems involving neutrophils may drive autoimmune diseases of the kidneys by turning neutrophils into cells that activate T cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 30, 1999 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $175,000 |
| NIH project number | 7R01HL065095-27 |
| Project ID | NIH-11473498 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with autoimmune kidney diseases (such as lupus nephritis) or related autoimmune conditions who have immune-related kidney involvement.
✕Less likely to help
Patients without autoimmune kidney involvement or those not showing immune-mediated kidney pathology may not benefit from this research.
What this research studies
If you have an autoimmune kidney disease or are affected by related immune problems, this renewal study explores how neutrophils, a type of white blood cell, become highly active antigen-presenting cells after interacting with immune complexes. The work uses human cells and mouse models to understand how these neutrophil-derived antigen-presenting cells could kick off stronger immune responses in the kidneys. Findings could point to new targets for therapies aimed at reducing kidney inflammation and tissue damage. The team plans to connect laboratory observations to patient data, including samples from lupus patients, to gauge relevance to human disease.
Why it matters
Potential benefit: Could lead to new treatment strategies that dampen harmful immune activation in autoimmune kidney diseases.
How similar studies have gone: Early data show neutrophils can become antigen-presenting cells; the approach has shown promise in models and human samples but remains translationally hopeful.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Mayadas, Tanya N — University of Rochester
- Study coordinator: Mayadas, Tanya N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.