Identification and cascade testing for familial hypercholesterolemia (IMPACT-FH)
Official title: Identification Methods, Patient Activation, and Cascade Testing for FH: IMPACT-FH
Funded at Geisinger Clinic · NIH-11413585 · Data updated 2026-11-12
A doctor and team are testing how to find people with FH earlier and use family testing to prevent heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Geisinger Clinic NIH-funded |
| Lab location | 1 site (Danville, United States) |
| Project start | August 15, 2019 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $727,667 |
| NIH project number | 5R01HL148246-07 |
| Project ID | NIH-11413585 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals at risk for or diagnosed with familial hypercholesterolemia and their first-degree relatives
✕Less likely to help
People without FH or without a health care system willing to implement cascade testing may not directly benefit.
What this research studies
This project looks at how to expand FH screening from specialized clinics into general primary care, so more people with FH can be identified early. It also studies the costs and sustainability of starting and maintaining cascade testing to identify relatives who may also have FH. The work builds on prior IMPACT-FH findings to see what fits best in diverse health systems and how to implement it in real-world settings. The goal is to reduce missed diagnoses and help families start lipid-lowering treatment sooner to lower ASCVD risk.
Why it matters
Potential benefit: If successful, more people with FH will be identified early and receive timely treatment to lower their risk of heart disease.
How similar studies have gone: Previous IMPACT-FH work showed potential for cascade testing in specialty care; this renewal tests broader, real-world applicability.
Where this research is happening
-
Geisinger Clinic
Danville, United States Active
Researchers
- Principal investigator: Morales Reyes, Ana — Geisinger Clinic
- Study coordinator: Morales Reyes, Ana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.