Identification and family-based testing to prevent heart disease in FH patients
Official title: Identification Methods, Patient Activation, and Cascade Testing for FH: IMPACT-FH
Funded at Geisinger Clinic · NIH-11634383 · Data updated 2026-11-12
This project helps people with familial hypercholesterolemia and their families get identified early and start treatment to prevent heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Geisinger Clinic NIH-funded |
| Lab location | 1 site (Danville, United States) |
| Project start | August 15, 2019 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $42,927 |
| NIH project number | 3R01HL148246-07S1 |
| Project ID | NIH-11634383 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include adults or children with FH or a family history suggesting FH who could participate in screening, testing, and cost-analysis activities.
✕Less likely to help
Individuals without FH or who cannot participate in primary-care–based screening and cascade-testing activities may not benefit.
What this research studies
If you have a family history or a diagnosis of familial hypercholesterolemia, this project explores how to better find you and your relatives through practical screening in primary care. It looks at how much cascade testing (testing relatives of someone with FH) costs and how to make it work in real clinics beyond specialized genetics centers. The work will compare different ways to implement the program and estimate overall costs and long-term sustainability. The goal is to show how to roll out effective FH screening so more people with high cholesterol can start lowering their risk sooner.
Why it matters
Potential benefit: If successful, the approach could help many people with FH get diagnosed earlier and begin life-saving treatment.
How similar studies have gone: Previous IMPACT-FH work showed promise in specialty care; this renewal tests applicability in general primary care settings.
Where this research is happening
-
Geisinger Clinic
Danville, United States Active
Researchers
- Principal investigator: Morales Reyes, Ana — Geisinger Clinic
- Study coordinator: Morales Reyes, Ana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.