Genomic patterns of weight change and heart-disease risk across adulthood
Official title: Genomic Architecture of Lifecourse Patterns of Adiposity Change and Cardiometabolic Risk
Funded at Geisinger Clinic · NIH-11450637 · Data updated 2026-11-12
A long-term study looking at how changes in body mass over adulthood relate to cardiometabolic disease, especially diabetes, using genetic and other biological data.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Geisinger Clinic NIH-funded |
| Lab location | 1 site (Danville, United States) |
| Project start | September 22, 2020 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $857,714 |
| NIH project number | 2R01DK122503-06A1 |
| Project ID | NIH-11450637 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or at risk for adult-onset diabetes who have long-term follow-up data or are willing to contribute biological samples and health information.
✕Less likely to help
Individuals without access to the study cohorts or without relevance to obesity-related cardiometabolic pathways may not directly benefit.
What this research studies
If you have or are at risk for adult-onset diabetes, this project will follow people over many years to map how weight history and biology combine to affect health. Researchers will use large group studies and medical records to track BMI changes, metabolic markers, and genetic information, aiming to connect weight trajectories with disease risk. The goal is to uncover mechanisms and identify precision prevention strategies that could later help tailor interventions for individuals based on their weight history and biology.
Why it matters
Potential benefit: Gaining clearer insights into who is at higher risk for cardiometabolic diseases and how weight patterns over adulthood influence that risk, which could guide personalized prevention.
How similar studies have gone: Previous research shows that weight trajectories influence disease risk, and this study builds on that with expanded longitudinal data and multi-omics.
Where this research is happening
-
Geisinger Clinic
Danville, United States Active
Researchers
- Principal investigator: Justice, Anne — Geisinger Clinic
- Study coordinator: Justice, Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.