HPV, HIV, and mouth bacteria in Nigerian youth
Official title: HPV, HIV and Oral Microbiota Interplay in Nigerian Youth (HOMINY)
Funded at University of Pennsylvania · NIH-11381961 · Data updated 2026-11-12
A study following HIV-exposed and HIV-infected youth to understand how oral HPV infections appear and persist, and how the mouth’s microbes might influence cancer risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $917,237 |
| NIH project number | 5R01DE032216-05 |
| Project ID | NIH-11381961 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are youth in the defined age ranges with HIV infection or exposure, and their HIV-positive or HIV-negative mothers, in the United States.
✕Less likely to help
Some participants may not experience immediate health benefits, but their data will help understand risk factors and prevention.
What this research studies
This project follows groups of children and their mothers to observe how oral HPV infections develop over time in youth with perinatal HIV exposure or infection. Researchers will collect saliva and other samples to map the oral microbiome and identify microbial pathways associated with HPV persistence. The study uses a prospective observational design in a large cohort to explore how HIV status and antiretroviral therapy may affect oral health and cancer risk later in life. Outcomes could inform targeted vaccine strategies and oral cancer prevention in at-risk youth.
Why it matters
Potential benefit: If successful, it could guide targeted HPV prevention and oral health interventions for youth affected by HIV exposure or infection.
How similar studies have gone: There is growing evidence linking HIV and oral microbiomes to HPV dynamics, but pediatric-specific data are limited and this study would add new insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Coker, Modupe — University of Pennsylvania
- Study coordinator: Coker, Modupe
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.