NIH-funded research R01 grant

How we make tough choices in the brain

Official title: Mechanisms of multi-attribute decision-making

Funded at New York University · NIH-11412722 · Data updated 2026-11-12

This project studies how the brain weighs different attributes (like costs and benefits) when people make complex decisions.

More Decision Making research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionNew York University
NIH-funded
Lab location1 site (New York, United States)
Project startSeptember 20, 2023
Project endJuly 31, 2028
Funding year2026
Award (this year)$627,687
NIH project number5R01MH134845-04
Project IDNIH-11412722 on NIH RePORTER

Who could benefit from this research

Could help

Ideal participants may include adults with typical decision-making patterns who can complete behavioral tasks while undergoing brain measurements.

Less likely to help

People without interest or ability to participate in neuroimaging or behavioral tasks may not benefit directly.

What this research studies

Researchers at NYU are exploring how the orbitofrontal cortex helps us weigh multiple attributes during decision making. They will compare different brain and behavior models to see which best explains how people choose between options with varying costs and qualities. The study uses a multi-modal approach to map how information is processed in the brain during multi-attribute choices. Findings could help explain why decision-making is altered in certain psychiatric conditions and guide future approaches to improve it. The work aims to connect brain activity with the computations behind value-based decisions.

Why it matters

Potential benefit: A better understanding of how people make complex choices could inform treatments for decision-making problems in psychiatric disorders and improve interventions.

How similar studies have gone: Previous work in decision neuroscience supports multi-model explanations of how choices are made, with ongoing exploration needed for definitive links to neural processes.

Where this research is happening

  • New York University
    New York, United States
    Active

Researchers

  • Principal investigator: Rich, Erin L — New York University
  • Study coordinator: Rich, Erin L

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.