How viruses manipulate a specific protein modification during infection
Official title: Adenoviral manipulation of arginine methylation
Funded at University of Pennsylvania · NIH-11098411 · Data updated 2026-11-12
This study is looking at how a common virus called adenovirus changes the way certain proteins in our cells are modified, which is important for how our body processes RNA, and it aims to help us understand how the virus works and find new ways to treat infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31AI181460-02 |
| Project ID | NIH-11098411 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals infected with human Adenovirus or those at risk of such infections.
✕Less likely to help
Patients with viral infections caused by other types of viruses unrelated to Adenovirus may not benefit from this research.
What this research studies
This research investigates how human Adenovirus (AdV) affects arginine methylation, a process that modifies proteins and is crucial for RNA processing. By studying the interactions between the virus and host cellular machinery, the project aims to uncover the roles of arginine methylation during viral infection. The approach involves using AdV as a model to observe changes in protein behavior and localization, particularly focusing on the effects of the virus on RNA-binding proteins and the enzymes responsible for their modification. This could provide insights into viral strategies and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating viral infections by targeting the mechanisms viruses use to manipulate host cellular processes.
How similar studies have gone: Previous research has shown that understanding viral manipulation of host processes can lead to significant advancements in treatment strategies, indicating a promising avenue for this investigation.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Abbott, Amber — University of Pennsylvania
- Study coordinator: Abbott, Amber
Related research
Other NIH-funded projects on the same topics.
-
Comparing universal and guideline-directed genetic testing for young adults with cancer
This study is looking at whether a broader genetic test can help young adults with cancer find inherited risks that regular tests might miss, so they can get better treatment and care tailored just for them.
-
Better, searchable data for human pain biology
A data integration center will standardize, combine, and share molecular and cellular data from human pain research to help scientists understand how pain works and to accelerate discoveries.
-
Understanding how sweat glands form and work to help burn and skin injury patients
A study at the University of Pennsylvania looks at how sweat glands develop and function, with the goal of informing treatments for people who suffer traumatic skin injuries.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Understanding how a special airway cell helps protect and repair breathing passages
A researcher is studying a newly found airway cell called the hillock to see how it protects the airways and helps repair them after injury, with the aim of helping people with asthma, COPD, or bronchiectasis.
-
Defining TMJ cartilage progenitors and their regulatory niche for TMJ regeneration
Researchers are studying the cells that could help repair the jaw’s cartilage in TMJ osteoarthritis to lay the groundwork for regenerative therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.