How viruses manipulate a specific protein modification during infection
Adenoviral manipulation of arginine methylation
This study is looking at how a common virus called adenovirus changes the way certain proteins in our cells are modified, which is important for how our body processes RNA, and it aims to help us understand how the virus works and find new ways to treat infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11098411 on NIH RePORTER |
What this research studies
This research investigates how human Adenovirus (AdV) affects arginine methylation, a process that modifies proteins and is crucial for RNA processing. By studying the interactions between the virus and host cellular machinery, the project aims to uncover the roles of arginine methylation during viral infection. The approach involves using AdV as a model to observe changes in protein behavior and localization, particularly focusing on the effects of the virus on RNA-binding proteins and the enzymes responsible for their modification. This could provide insights into viral strategies and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with human Adenovirus or those at risk of such infections.
Not a fit: Patients with viral infections caused by other types of viruses unrelated to Adenovirus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating viral infections by targeting the mechanisms viruses use to manipulate host cellular processes.
How similar studies have performed: Previous research has shown that understanding viral manipulation of host processes can lead to significant advancements in treatment strategies, indicating a promising avenue for this investigation.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Abbott, Amber — University of Pennsylvania
- Study coordinator: Abbott, Amber
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.