How Trpv4 channels affect lymphatic function and metabolic syndrome
Official title: Trpv4 regulation of lymphatic vascular function: Implications in metabolic syndrome
Funded at Tulane University of Louisiana · NIH-11032036 · Data updated 2026-11-12
This study is looking at how a specific channel in our lymphatic system, called Trpv4, affects fluid balance and immune health, especially in people dealing with obesity and metabolic syndrome, to find ways to improve lymphatic function and overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | March 20, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $436,811 |
| NIH project number | 5R01HL168568-03 |
| Project ID | NIH-11032036 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from obesity or metabolic syndrome who may experience lymphatic dysfunction.
✕Less likely to help
Patients who do not have obesity or metabolic syndrome may not benefit from this research.
What this research studies
This research investigates the role of Trpv4 channels in the lymphatic system, which is crucial for fluid balance and immune function. The study aims to understand how obesity and metabolic syndrome lead to lymphatic dysfunction and how improving lymphatic function could serve as a treatment option. By examining the effects of Trpv4 channel activity on lymphatic vessels, the research seeks to uncover potential therapeutic strategies to enhance lymphatic health in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lymphatic function and help manage obesity and metabolic syndrome.
How similar studies have gone: While the specific role of Trpv4 in lymphatic function is relatively unexplored, related research has shown that targeting vascular function can lead to significant improvements in metabolic health.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Castorena, Jorge Augusto — Tulane University of Louisiana
- Study coordinator: Castorena, Jorge Augusto
Related research
Other NIH-funded projects on the same topics.
-
Integrated biomarker study of metabolic syndrome in pregnant women with HIV on DTG-based ART
Researchers will look for biological signs in pregnant women with HIV on a DTG-based regimen to understand why weight gain and metabolic problems happen and how these affect pregnancy.
-
Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on DTG-based ART
This project looks at why some pregnant women living with HIV on a common DTG-based therapy gain weight or develop metabolic problems, by studying their proteins and metabolites across four sites in the US and Nigeria.
-
Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on DTG-based therapy
This project looks at markers in pregnant women living with HIV who are on a DTG-containing regimen to understand why some develop metabolic problems during pregnancy.
-
Metabolic syndrome and brain support cells: how it may lead to Alzheimer’s disease
A researcher is studying how midlife metabolic problems like diabetes and obesity may disrupt brain cells that support neurons, potentially leading to Alzheimer's disease and related dementia in later life.
-
GLP-1 medicines to improve heart, kidney, and metabolic health for people with HIV and type 2 diabetes
A real-world study will look at how GLP-1 receptor agonists affect heart and kidney health and lifetime costs for people living with HIV and type 2 diabetes.
-
A new metabolic risk score to predict heart disease in Yup’ik Alaska Native adults
A new, questions-free way to measure heart-disease risk in Yup’ik Alaska Native adults by combining everyday health clues with home-life factors.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.