How titanium affects inflammation around dental implants
Official title: Impact of Titanium-mediated Oxidative Stress on LPS/TLR4 Signaling
Funded at Rutgers Biomedical and Health Sciences · NIH-11009005 · Data updated 2026-11-12
This study looks at how titanium used in dental implants might affect your immune system and lead to issues like peri-implantitis, helping us find better ways to ensure your dental implants stay healthy and successful.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | December 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $75,084 |
| NIH project number | 5F32DE033622-02 |
| Project ID | NIH-11009005 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have dental implants and are experiencing or at risk of developing peri-implantitis.
✕Less likely to help
Patients without dental implants or those not at risk for peri-implantitis may not benefit from this research.
What this research studies
This research investigates the role of titanium in causing oxidative stress and its impact on the immune response related to dental implants. It focuses on how the body’s immune system, particularly through Toll-like receptor (TLR) signaling, responds to bacterial components in the mouth that can lead to peri-implantitis, a condition that threatens the success of dental implants. By understanding these mechanisms, the research aims to identify potential therapeutic strategies to improve dental implant outcomes for patients.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options for patients suffering from peri-implantitis, ultimately improving the longevity and success of dental implants.
How similar studies have gone: Previous research has shown promising results in understanding immune responses related to dental implants, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Siddiqui, Danyal — Rutgers Biomedical and Health Sciences
- Study coordinator: Siddiqui, Danyal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.