How the gut microbiome affects brain development in preterm infants
The Gut Microbiome Brain Axis and Preterm Infants
This study is looking at how the bacteria in the guts of preterm babies might affect their brain development, hoping to find ways to support their growth and health as they grow up.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11010353 on NIH RePORTER |
What this research studies
This research investigates the relationship between the gut microbiome and brain development in preterm infants, a vulnerable group at risk for long-term neurodevelopmental issues. By analyzing fecal and blood samples from preterm infants in the NICU, the study aims to identify specific gut microbiome taxa and metabolites that may influence neurodevelopmental outcomes. The research will track changes over time to understand how early microbiome composition can affect brain health as these infants grow. This approach combines advanced genetic sequencing techniques with clinical observations to uncover potential interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are preterm infants who are currently receiving care in a neonatal intensive care unit (NICU).
Not a fit: Patients who are not preterm or those who are beyond the neonatal stage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving neurodevelopmental outcomes in preterm infants.
How similar studies have performed: Previous research has shown promising results in understanding the gut-brain axis, suggesting that modifying the gut microbiome could positively impact neurodevelopment.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Claud, Erika C — University of Chicago
- Study coordinator: Claud, Erika C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.