How RNA structures are regulated during development
Official title: Regulation of RNA condensates by RNA helicases in development
Funded at University of Wisconsin-Madison · NIH-11020763 · Data updated 2026-11-12
This study is looking at how tiny clusters of RNA and proteins, called RNA condensates, help cells develop, using a small worm called C. elegans to see how certain proteins affect these clusters and their functions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | February 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $375,430 |
| NIH project number | 1R35GM157010-01 |
| Project ID | NIH-11020763 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the biological mechanisms of development and RNA-related conditions.
✕Less likely to help
Patients with conditions unrelated to RNA function or development may not receive any benefit from this research.
What this research studies
This research investigates the role of RNA condensates, which are clusters of RNA and proteins that form without membranes, in the development of cells. By studying these condensates in the model organism C. elegans, the research aims to understand how RNA helicases, a type of protein, influence the formation and function of these structures. The approach involves advanced techniques to measure and manipulate these condensates, providing insights into their biological significance and potential roles in cellular organization.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of cellular processes that are crucial for development and may inform treatments for diseases related to RNA dysfunction.
How similar studies have gone: While the study of RNA condensates is a growing field, the specific regulatory mechanisms being investigated here are relatively novel and have not been extensively tested in previous research.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Putnam, Andrea Arlton — University of Wisconsin-Madison
- Study coordinator: Putnam, Andrea Arlton
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.