How RNA changes help organisms adapt to their environments
Official title: The functional and adaptive roles of RNA recoding
Funded at Johns Hopkins University · NIH-11212412 · Data updated 2026-11-12
This study looks at how certain changes in RNA help cephalopods and fungi adapt and function better, focusing on how these changes affect the proteins that carry out important jobs in their cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 4R00GM151485-03 |
| Project ID | NIH-11212412 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions related to cellular function and adaptation, particularly those involving cephalopods or fungal interactions.
✕Less likely to help
Patients with conditions unrelated to RNA recoding or those not affected by cephalopod or fungal biology may not receive any benefit from this research.
What this research studies
This research investigates the role of RNA recoding in cephalopods and fungi, focusing on how it affects protein function and cellular processes. By examining how RNA editing alters the amino acid sequences of proteins, the study aims to understand its impact on essential functions like transport and DNA replication. The research employs various assays to observe these changes in living organisms, providing insights into the molecular mechanisms that support adaptation and physiological needs.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding how organisms adapt to their environments, potentially informing medical and biotechnological applications.
How similar studies have gone: While the specific focus on RNA recoding in cephalopods and fungi is relatively novel, similar research in RNA editing has shown promising results in understanding protein function and adaptation in other organisms.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Rangan, Kavita — Johns Hopkins University
- Study coordinator: Rangan, Kavita
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.