How reducing calorie intake affects inflammation in older adults
Caloric restriction-driven immunometabolic checkpoints of inflammation
This study is looking at how eating fewer calories might help older adults, aged 65 and up, stay healthier by reducing inflammation and boosting their immune system, which could be especially helpful in fighting age-related diseases like Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11055321 on NIH RePORTER |
What this research studies
This research investigates the effects of caloric restriction on inflammation and immune function in individuals aged 65 and older. By analyzing data from the CALERIE-II clinical trial, the study aims to understand how reducing calorie intake can influence health and longevity in older adults. The researchers will examine immune cell samples, plasma, and adipose tissue to identify mechanisms that could help mitigate age-related diseases, including Alzheimer's disease. The findings could provide insights into dietary interventions that promote healthier aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 65 and older who are interested in the effects of diet on health and aging.
Not a fit: Patients under the age of 65 or those with severe acute health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to dietary recommendations that help reduce inflammation and improve health outcomes for older adults.
How similar studies have performed: Previous research on caloric restriction in animal models has shown promising results, but this study aims to explore its effects in humans, making it a novel investigation.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Dixit, Vishwa Deep — Yale University
- Study coordinator: Dixit, Vishwa Deep
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.