Calorie reduction's effects on immune-linked inflammation in aging
Caloric restriction-driven immunometabolic checkpoints of inflammation
This project looks at whether eating fewer calories changes immune activity and chronic inflammation in adults, especially older people, to help lower age-related disease risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11304067 on NIH RePORTER |
What this research studies
Researchers will analyze blood, immune cells, and fat tissue samples collected from people who took part in a two-year moderate calorie-reduction program (CALERIE-II). Lab tests and molecular profiling will search for immune and metabolic pathways that calm the chronic inflammation that comes with aging. The team will compare signals in plasma, immune cells, and adipose tissue to find biomarkers and potential targets for therapies. Results could point to new treatments or lifestyle approaches to reduce risks for Alzheimer's and other age-related illnesses.
Who could benefit from this research
Good fit: Ideal candidates are adults interested in research on aging and inflammation—particularly older adults or people willing to participate in calorie-reduction studies or donate blood and fat tissue samples.
Not a fit: People under 18, or those with medical conditions that make calorie reduction unsafe, are unlikely to benefit from or be eligible for this work.
Why it matters
Potential benefit: If successful, this work could identify biological targets or markers that help reduce chronic inflammation and lower the risk or severity of age-related diseases like Alzheimer's.
How similar studies have performed: Animal studies show calorie restriction can extend healthspan, and CALERIE-II is among the first large human efforts providing material to explore these immune and metabolic effects in people.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Dixit, Vishwa Deep — Yale University
- Study coordinator: Dixit, Vishwa Deep
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.