How postpartum estrogen withdrawal affects brain function and behavior
Official title: Identifying the mechanism by which postpartum estrogen withdrawal impacts mesolimbic brain circuitry and motivated behaviors
Funded at Haverford College · NIH-10291568 · Data updated 2026-11-12
This study looks at how a quick drop in estrogen after having a baby affects the brain and feelings, especially in new moms, to help us understand why some might struggle with mood and anxiety issues during this time.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Haverford College NIH-funded |
| Lab location | 1 site (Haverford, United States) |
| Project start | July 16, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2021 |
| Award (this year) | $439,072 |
| NIH project number | 1R15MH125282-01A1 |
| Project ID | NIH-10291568 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are postpartum women experiencing mood or anxiety disorders.
✕Less likely to help
Patients who are not postpartum or who do not experience mood or anxiety disorders may not receive benefit from this research.
What this research studies
This research investigates the effects of a sudden drop in estrogen levels after childbirth on brain circuitry and behaviors related to motivation and mood. It focuses on understanding how this hormonal change may lead to psychological disorders in new mothers. Using a rodent model that simulates postpartum conditions, the study examines changes in brain activity and behavior linked to estrogen withdrawal. The goal is to uncover the underlying mechanisms that contribute to postpartum mood and anxiety disorders.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for postpartum mood and anxiety disorders.
How similar studies have gone: While the specific approach of examining estrogen withdrawal's impact on mesolimbic circuitry is novel, related research has shown that hormonal changes can significantly affect mood and behavior.
Where this research is happening
-
Haverford College
Haverford, United States Active
Researchers
- Principal investigator: Been, Laura Elizabeth — Haverford College
- Study coordinator: Been, Laura Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.