How postpartum estrogen withdrawal affects brain function and behavior
Identifying the mechanism by which postpartum estrogen withdrawal impacts mesolimbic brain circuitry and motivated behaviors
['FUNDING_R15'] · HAVERFORD COLLEGE · NIH-10291568
This study looks at how a quick drop in estrogen after having a baby affects the brain and feelings, especially in new moms, to help us understand why some might struggle with mood and anxiety issues during this time.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HAVERFORD COLLEGE (nih funded) |
| Locations | 1 site (HAVERFORD, UNITED STATES) |
| Trial ID | NIH-10291568 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of a sudden drop in estrogen levels after childbirth on brain circuitry and behaviors related to motivation and mood. It focuses on understanding how this hormonal change may lead to psychological disorders in new mothers. Using a rodent model that simulates postpartum conditions, the study examines changes in brain activity and behavior linked to estrogen withdrawal. The goal is to uncover the underlying mechanisms that contribute to postpartum mood and anxiety disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are postpartum women experiencing mood or anxiety disorders.
Not a fit: Patients who are not postpartum or who do not experience mood or anxiety disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for postpartum mood and anxiety disorders.
How similar studies have performed: While the specific approach of examining estrogen withdrawal's impact on mesolimbic circuitry is novel, related research has shown that hormonal changes can significantly affect mood and behavior.
Where this research is happening
HAVERFORD, UNITED STATES
- HAVERFORD COLLEGE — HAVERFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BEEN, LAURA ELIZABETH — HAVERFORD COLLEGE
- Study coordinator: BEEN, LAURA ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anxiety Disorders, Mental disorders, Mental health disorders, Psychiatric Disease, Psychiatric Disorder