How nutrient regulation affects gene expression and development in plants
Official title: Nutrient regulation of Alternative splicing and transcription by O-GlcNAcylation
Funded at Carnegie Institution of Washington, D.c. · NIH-10769770 · Data updated 2026-11-12
This study looks at how a special protein in plants helps control their growth and development, especially during important stages like seed germination and flowering, and it aims to understand how nutrients affect these processes, which could help improve farming practices.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Carnegie Institution of Washington, D.c. NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | December 1, 2019 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $339,213 |
| NIH project number | 5R01GM135706-05 |
| Project ID | NIH-10769770 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are those involved in agricultural sciences or plant biology, particularly those interested in genetic regulation and development.
✕Less likely to help
Patients not involved in agricultural sciences or those focused solely on human health may not receive direct benefits from this research.
What this research studies
This research investigates the molecular mechanisms that control gene expression and developmental transitions, focusing on the role of a specific protein, AtAcinus, in plants. It explores how this protein is modified by O-GlcNAcylation and its impact on RNA alternative splicing, which is crucial for cellular regulation and development. By using advanced techniques such as proteomics and genetics in the Arabidopsis model system, the research aims to uncover how nutrient signals influence key developmental processes like seed germination and flowering. The findings could provide insights into both plant biology and potential applications in agriculture.
Why it matters
Potential benefit: If successful, this research could lead to improved agricultural practices by enhancing our understanding of plant growth and development.
How similar studies have gone: Other research has shown success in understanding gene regulation through similar molecular mechanisms, indicating a promising avenue for further exploration.
Where this research is happening
-
Carnegie Institution of Washington, D.c.
Washington, United States Active
Researchers
- Principal investigator: Xu, Shouling — Carnegie Institution of Washington, D.c.
- Study coordinator: Xu, Shouling
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.