How gut bacteria influence lifespan and aging
Official title: Host mechanisms of gut colonization by commensal bacteria that affect lifespan
Funded at Carnegie Institution of Washington, D.c. · NIH-10890814 · Data updated 2026-11-12
This study is looking at how certain good bacteria in the gut can help us live longer and age better, using fruit flies to learn more about how these bacteria interact with our bodies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Carnegie Institution of Washington, D.c. NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | August 15, 2022 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $387,672 |
| NIH project number | 5R01DK128454-03 |
| Project ID | NIH-10890814 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals interested in gut health, aging, and the role of probiotics.
✕Less likely to help
Patients with conditions unrelated to gut health or aging may not receive any benefit from this research.
What this research studies
This research investigates how specific gut bacteria interact with host tissues to affect lifespan and aging. By studying the fruit fly Drosophila melanogaster, researchers aim to identify the host cells, genes, and molecules that facilitate the colonization of beneficial bacteria like Lactobacillus plantarum and Acetobacter. The study employs advanced techniques such as single-cell RNA sequencing to uncover the mechanisms that create a supportive environment for these bacteria in the gut. Understanding these interactions could lead to insights into how gut health impacts overall longevity.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting gut health and potentially extending lifespan through targeted bacterial therapies.
How similar studies have gone: Other research has shown promising results in understanding the role of gut bacteria in health, indicating that this approach could yield valuable insights.
Where this research is happening
-
Carnegie Institution of Washington, D.c.
Washington, United States Active
Researchers
- Principal investigator: Ludington, William Basil — Carnegie Institution of Washington, D.c.
- Study coordinator: Ludington, William Basil
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.