How certain proteins in probiotics help them attach to the gut
Official title: Serine-rich repeat proteins in evolution of Lactobacillus-host specificity
Funded at Carnegie Institution of Washington, D.c. · NIH-10808208 · Data updated 2026-11-12
This study is looking at how certain proteins in friendly bacteria, like Lactobacillus plantarum, help them stick to your gut, which could lead to better probiotics for keeping your digestive system healthy.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Carnegie Institution of Washington, D.c. NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | March 13, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $209,375 |
| NIH project number | 5R21AI173779-02 |
| Project ID | NIH-10808208 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in improving their gut health or those suffering from gastrointestinal issues.
✕Less likely to help
Patients with no interest in probiotics or those who do not have gastrointestinal health concerns may not benefit from this research.
What this research studies
This research investigates how specific proteins called serine-rich repeat proteins (SRRPs) in probiotic bacteria, particularly Lactobacillus plantarum, help these bacteria attach to the gut lining. By understanding the evolution and function of these proteins, the research aims to uncover how they enhance the bacteria's ability to colonize and thrive in the digestive tract. The study will utilize advanced imaging techniques to observe these interactions in living animals, providing insights into the competitive dynamics between different bacterial species in the gut. This knowledge could lead to improved probiotic formulations that better support gut health.
Why it matters
Potential benefit: If successful, this research could lead to more effective probiotics that enhance gut health and prevent infections.
How similar studies have gone: Previous research has shown promising results in understanding the role of bacterial adhesion in gut health, making this approach both relevant and potentially impactful.
Where this research is happening
-
Carnegie Institution of Washington, D.c.
Washington, United States Active
Researchers
- Principal investigator: Ludington, William Basil — Carnegie Institution of Washington, D.c.
- Study coordinator: Ludington, William Basil
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.