How Notch signaling affects bone cell function
Official title: Fringe regulation of Notch signaling in osteoclasts
Funded at Eastern Washington University · NIH-10850078 · Data updated 2026-11-12
This study is looking at how certain proteins affect the way bone cells called osteoclasts work, which is important for keeping your bones healthy, and it’s for anyone interested in understanding how our bodies manage bone strength.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Eastern Washington University NIH-funded |
| Lab location | 1 site (Cheney, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $120,204 |
| NIH project number | 1R16DE034585-01 |
| Project ID | NIH-10850078 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions that affect bone density, such as osteoporosis or metastatic bone disease.
✕Less likely to help
Patients with non-bone-related conditions or those not experiencing issues with bone density may not benefit from this research.
What this research studies
This research investigates the role of Notch signaling in the differentiation and function of osteoclasts, which are cells responsible for bone resorption. It focuses on how different members of the Fringe family of enzymes modify Notch receptors through glycosylation, impacting their activation and the resulting osteoclast activity. By manipulating the expression of these enzymes, the study aims to understand how varying levels of Notch signaling can either promote or inhibit osteoclast formation and function, which is crucial for maintaining bone health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to bone density and autoimmune diseases affecting bone health.
How similar studies have gone: While the specific approach of manipulating Fringe enzymes in osteoclasts is novel, similar studies have shown that targeting Notch signaling can influence bone health.
Where this research is happening
-
Eastern Washington University
Cheney, United States Active
Researchers
- Principal investigator: Ashley, Jason Waid — Eastern Washington University
- Study coordinator: Ashley, Jason Waid
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.