Investigating how a specific protein affects the harmful traits of a common bacterial pathogen.
Official title: The role of master regulator NtrC in amyloid fibril dependent pathogenic traits of Pseudomonas aeruginosa
Funded at Eastern Washington University · NIH-10990786 · Data updated 2026-11-12
This study is looking at how a specific protein in the harmful bacteria Pseudomonas aeruginosa helps it survive and resist treatments, with the goal of finding new ways to help people who are dealing with infections caused by this tough germ.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Eastern Washington University NIH-funded |
| Lab location | 1 site (Cheney, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $355,087 |
| NIH project number | 7R15GM150043-02 |
| Project ID | NIH-10990786 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with infections caused by Pseudomonas aeruginosa, particularly those who have not responded to standard antibiotic treatments.
✕Less likely to help
Patients with infections caused by other types of bacteria or those who do not have any bacterial infections may not benefit from this research.
What this research studies
This research focuses on Pseudomonas aeruginosa, a dangerous bacterium that can cause severe infections in humans. The project aims to understand how a protein called NtrC influences the bacterium's ability to adapt and resist treatments, including antibiotics. By disrupting the regulatory network that controls the expression of genes related to this protein, the researchers hope to uncover new strategies to combat infections caused by P. aeruginosa. This work could lead to better therapeutic approaches for patients suffering from infections.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively combat infections caused by Pseudomonas aeruginosa.
How similar studies have gone: While the specific approach of targeting the NtrC protein is novel, similar research has shown promise in understanding bacterial pathogenesis and developing new treatment strategies.
Where this research is happening
-
Eastern Washington University
Cheney, United States Active
Researchers
- Principal investigator: Sarwar, Zaara — Eastern Washington University
- Study coordinator: Sarwar, Zaara
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.