Investigating how a specific protein affects the harmful traits of a common bacteria.
Equipment Supplement for 7R15GM150043-02: The role of master regulator NtrC in amyloid fibril dependent pathogenic traits of Pseudomonas aeruginosa
['FUNDING_R15'] · EASTERN WASHINGTON UNIVERSITY · NIH-11035787
This study is looking at how a specific protein in the bacteria Pseudomonas aeruginosa helps it survive and resist treatments, with the goal of finding new ways to fight infections for people who are affected by this tough germ.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EASTERN WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (CHENEY, UNITED STATES) |
| Trial ID | NIH-11035787 on ClinicalTrials.gov |
What this research studies
This research focuses on Pseudomonas aeruginosa, a bacteria that can cause severe infections in humans. The project aims to understand how a protein called NtrC helps this bacteria adapt and resist treatments, including antibiotics. By disrupting the regulatory networks that control the expression of genes related to this protein, the researchers hope to find new ways to combat the bacteria's ability to infect and damage human tissues. Patients may benefit from insights gained about how to better target this pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by Pseudomonas aeruginosa, particularly those with compromised immune systems or chronic conditions.
Not a fit: Patients with infections caused by other types of bacteria that do not involve Pseudomonas aeruginosa may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively combat infections caused by Pseudomonas aeruginosa.
How similar studies have performed: While the specific approach of targeting the NtrC protein is novel, similar research has shown promise in understanding bacterial resistance mechanisms.
Where this research is happening
CHENEY, UNITED STATES
- EASTERN WASHINGTON UNIVERSITY — CHENEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SARWAR, ZAARA — EASTERN WASHINGTON UNIVERSITY
- Study coordinator: SARWAR, ZAARA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.