How nasal infections affect asthma attacks
Official title: The nose-lung cross talk in upper respiratory virus infection induced asthma exacerbations
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11111038 · Data updated 2026-11-12
This study is looking at how infections in your nose might make asthma worse, especially when you have a cold or other upper respiratory virus, and it hopes to find new ways to help manage asthma during these times.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | January 15, 2025 |
| Project end | March 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $718,962 |
| NIH project number | 7R01HL167271-03 |
| Project ID | NIH-11111038 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals with asthma who experience exacerbations related to upper respiratory infections.
✕Less likely to help
Patients with asthma who do not experience exacerbations due to upper respiratory infections may not benefit from this research.
What this research studies
This research investigates how infections in the nose can influence asthma exacerbations, particularly during upper respiratory virus infections. It aims to understand the immune mechanisms involved in this 'nose-lung cross talk' and how nasal infections can activate lung immunity without directly affecting the lungs. By studying these interactions in mice with experimental asthma, the research seeks to uncover the physiological and inflammatory responses triggered by nasal viral infections. The findings could provide insights into new treatment strategies for asthma exacerbations linked to respiratory infections.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for asthma exacerbations triggered by upper respiratory infections.
How similar studies have gone: Previous research has indicated that nasal infections can influence lung immunity, suggesting that this area of investigation may yield valuable insights.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Hua, Xiaoyang — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Hua, Xiaoyang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.