How NAD+ levels affect heart aging
Official title: Mitochondrial NAD+ Metabolism in Cardiac Aging
Funded at Oklahoma Medical Research Foundation · NIH-11063235 · Data updated 2026-11-12
This study is looking at how a substance called NAD+ affects heart health as we age, and it aims to find ways to improve heart function by adjusting a specific protein in heart cells, which could help tackle heart problems related to getting older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | April 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $539,182 |
| NIH project number | 5R01AG081855-02 |
| Project ID | NIH-11063235 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related heart conditions or those interested in preventive measures for heart health.
✕Less likely to help
Patients with acute heart conditions unrelated to aging may not benefit from this research.
What this research studies
This research investigates the role of nicotinamide adenine dinucleotide (NAD+) in the aging of the heart. It focuses on understanding how the transport of NAD+ into mitochondria, facilitated by a protein called SLC25A51, changes with age and impacts heart function. By using advanced genetic tools, the researchers aim to manipulate SLC25A51 levels in heart cells to see how this affects NAD+ levels and cardiac aging. The study will involve preclinical models to explore potential therapeutic strategies for boosting NAD+ as a way to combat age-related heart issues.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart health and function in older adults.
How similar studies have gone: Previous studies have shown promising results in boosting NAD+ levels to protect against aging and related diseases, indicating a potential for success in this approach.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Chiao, Ying Ann — Oklahoma Medical Research Foundation
- Study coordinator: Chiao, Ying Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.