How myeloid cells help heal tissue after inflammation
Myeloid sphingolipid regulation of tissue resolution and regeneration responses
This study is looking at how certain immune cells help control inflammation and healing in the body, focusing on a special receptor called S1PR1, to find new ways to improve recovery for people with conditions like liver failure and lung injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10887512 on NIH RePORTER |
What this research studies
This research investigates how myeloid cells, such as neutrophils and macrophages, interact with blood vessels to manage inflammation and promote healing. It focuses on understanding the role of a specific receptor, S1PR1, in regulating the resolution of inflammation and tissue regeneration. By studying how these cells can switch from causing damage to facilitating recovery, the research aims to develop new therapeutic approaches that enhance healing processes in conditions like acute liver failure and lung injury.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from conditions related to acute liver failure or lung injuries caused by viral infections.
Not a fit: Patients with chronic inflammatory diseases or those not experiencing acute inflammatory responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery from inflammatory injuries and enhance tissue regeneration.
How similar studies have performed: Previous research has shown promising results in understanding the role of myeloid cells in inflammation, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Hla, Timothy Tun — Boston Children's Hospital
- Study coordinator: Hla, Timothy Tun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.