How mRNA localization affects mitochondrial function in neurodegenerative diseases
Official title: mRNA localization as a driver of mitochondrial dysfunction during neurodegeneration
Funded at University of California, San Diego · NIH-10885700 · Data updated 2026-11-12
This study is looking at how the way certain messages in our cells are sent to the mitochondria affects their health, especially in diseases like Alzheimer's, and it hopes to find new ways to help improve treatment for people dealing with these age-related conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | April 15, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $391,668 |
| NIH project number | 1R21AG087396-01 |
| Project ID | NIH-10885700 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with age-related neurodegenerative diseases, particularly those with Alzheimer's disease.
✕Less likely to help
Patients with non-neurodegenerative conditions or those without cognitive impairment may not benefit from this research.
What this research studies
This research investigates the role of mRNA localization in the mitochondria and how it contributes to mitochondrial dysfunction in neurodegenerative diseases like Alzheimer's. The study aims to understand how the improper targeting of mitochondrial proteins leads to mitochondrial fragmentation, a common issue in these diseases. By exploring the mechanisms behind this process, the research seeks to identify potential therapeutic targets that could help restore mitochondrial function. Patients may benefit from insights gained that could lead to new treatments for age-related neurodegenerative conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve mitochondrial function and slow the progression of neurodegenerative diseases.
How similar studies have gone: Previous research has shown that targeting mitochondrial fragmentation can be protective in models of neurodegenerative diseases, indicating a promising avenue for further exploration.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Zid, Brian Matthew — University of California, San Diego
- Study coordinator: Zid, Brian Matthew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.