How mitochondria affect immune cell function in autoimmune diseases
Official title: Mitochondrial Membrane Dynamics in Th17 Cells
Funded at Johns Hopkins University · NIH-10888413 · Data updated 2026-11-12
This study is looking at how tiny parts of our cells called mitochondria affect a type of immune cell that can play a role in autoimmune diseases, with the hope of finding new ways to improve treatments for conditions like cancer and autoimmune disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 14, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $562,765 |
| NIH project number | 5R01AI172832-02 |
| Project ID | NIH-10888413 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases or those affected by conditions where Th17 cells play a critical role.
✕Less likely to help
Patients with non-autoimmune conditions or those not involving T cell dysfunction may not receive benefit from this research.
What this research studies
This research investigates the role of mitochondria in the activation and function of Th17 cells, a type of immune cell involved in autoimmune diseases. By examining how changes in mitochondrial shape and metabolism influence these cells, the study aims to uncover mechanisms that could lead to better therapies for conditions like cancer and autoimmune disorders. The approach includes detailed analysis of mitochondrial dynamics and their impact on T cell behavior, which could provide insights into immune responses. Patients may benefit from a deeper understanding of how to manipulate these immune cells for improved treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing autoimmune diseases and enhancing immune responses in cancer.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial function in immune cells, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Pearce, Erika L — Johns Hopkins University
- Study coordinator: Pearce, Erika L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.