How metabolism affects wound healing through immune cells
Metabolic regulation of macrophage-dependent wound healing in vivo
This study is looking at how changes in the way our bodies use energy affect immune cells called macrophages, which help heal wounds and manage inflammation, using zebrafish to see these changes in action, with hopes of finding new ways to treat inflammatory diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10932434 on NIH RePORTER |
What this research studies
This research investigates how changes in metabolism influence the function of macrophages, which are immune cells involved in wound healing and inflammation. Using zebrafish as a model, the study employs advanced imaging techniques to observe metabolic changes in macrophages during the healing process. By analyzing these changes in real-time, the research aims to uncover the mechanisms that regulate macrophage activity and their role in healing wounds. The findings could lead to new therapeutic strategies for treating inflammatory diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic wounds, inflammatory diseases, or conditions like atherosclerosis and autoimmune diseases.
Not a fit: Patients with acute injuries or those not affected by inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance wound healing and reduce inflammation in various diseases.
How similar studies have performed: While metabolic regulation of immune cells is a growing area of interest, this specific approach using real-time imaging in live models is relatively novel and has not been extensively tested.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Miskolci, Veronika — Rutgers Biomedical and Health Sciences
- Study coordinator: Miskolci, Veronika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.