How metabolism affects gene expression through epigenetic changes
Official title: Dynamics and molecular mechanisms linking metabolism and the epigenome
Funded at University of Wisconsin-Madison · NIH-10869896 · Data updated 2026-11-12
This study looks at how what we eat and other outside factors can change the way our cells work by affecting their genes, and it hopes to help people understand how their diet and environment can influence their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $698,211 |
| NIH project number | 5R35GM149279-02 |
| Project ID | NIH-10869896 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in understanding how their diet and lifestyle may influence their genetic expression and overall health.
✕Less likely to help
Patients with stable genetic conditions that are not influenced by metabolic or epigenetic factors may not benefit from this research.
What this research studies
This research investigates how the availability of nutrients and external signals influence the epigenetic state of cells, which in turn affects gene expression. It focuses on the role of specific biochemical modifications, such as DNA methylation and histone acetylation, that are regulated by enzymes using metabolites as co-factors. By understanding the dynamics of these modifications and how they are influenced by diet and other factors, the research aims to uncover the mechanisms that link metabolism to cellular function. Patients may benefit from insights into how their diet and environment can impact their health at a molecular level.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing diseases linked to metabolic and epigenetic dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between metabolism and epigenetic changes, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Denu, John M — University of Wisconsin-Madison
- Study coordinator: Denu, John M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.