How kidney clock proteins affect immune responses
Official title: Renal Circadian Clock Protein Regulation of Immune Activation
Funded at University of Florida · NIH-11017781 · Data updated 2026-11-12
This study is looking at how certain proteins in our bodies, which help keep our internal clocks running, affect the immune system in the kidneys, especially for people with chronic kidney disease, and it hopes to find out how a high-salt or low-potassium diet might cause more inflammation and harm to the kidneys, which could lead to better diet tips or treatments for kidney health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $137,752 |
| NIH project number | 5K01DK135929-02 |
| Project ID | NIH-11017781 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic kidney disease, particularly those affected by dietary factors like high salt intake.
✕Less likely to help
Patients with acute kidney injury or those not affected by chronic kidney disease may not benefit from this research.
What this research studies
This research investigates the role of circadian clock proteins in the kidneys and their impact on immune activation, particularly in the context of chronic kidney disease. It focuses on how a diet high in salt or low in potassium can lead to increased inflammation and kidney injury. Using advanced mouse models, the study aims to understand the mechanisms by which a specific protein, BMAL1, influences immune responses in kidney cells. Patients may benefit from insights that could lead to new dietary recommendations or treatments for kidney disease.
Why it matters
Potential benefit: If successful, this research could lead to improved management strategies for chronic kidney disease by targeting dietary factors and immune responses.
How similar studies have gone: Previous research has shown promising results in understanding the role of circadian rhythms in various diseases, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Crislip, Gene Ryan — University of Florida
- Study coordinator: Crislip, Gene Ryan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.