How immune cells affect fat cell function and energy use
Official title: Interleukin-10 mediated immune cell-adipocyte crosstalk in adipose thermogenesis
Funded at Icahn School of Medicine at Mount Sinai · NIH-11018584 · Data updated 2026-11-12
This study is looking at how a special immune molecule called interleukin-10 (IL10) affects fat cells and their ability to burn energy, which could help us find better ways to treat obesity and diabetes, so people can manage their weight and health more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $618,621 |
| NIH project number | 5R01DK136035-02 |
| Project ID | NIH-11018584 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over 21 years old who are dealing with insulin resistance or obesity-related health issues.
✕Less likely to help
Patients who do not have issues related to insulin sensitivity or obesity may not benefit from this research.
What this research studies
This research investigates the role of immune cells in the fat tissue environment and their impact on fat cell activation and energy expenditure. It focuses on a specific immune signaling molecule, interleukin-10 (IL10), which has been found to influence insulin sensitivity and glucose metabolism. By studying how IL10 affects fat cells and their thermogenic properties, the research aims to uncover mechanisms that could lead to improved treatments for conditions like obesity and diabetes. Patients may benefit from insights gained about how to enhance fat metabolism and manage weight-related health issues.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving insulin sensitivity and managing obesity-related conditions.
How similar studies have gone: Previous studies have shown promising results in understanding immune cell interactions with fat cells, suggesting that this approach could yield significant insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Rajbhandari, Prashant — Icahn School of Medicine at Mount Sinai
- Study coordinator: Rajbhandari, Prashant
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.