How immune cells affect fat cell function and energy use
Interleukin-10 mediated immune cell-adipocyte crosstalk in adipose thermogenesis
This study is looking at how a special immune molecule called interleukin-10 (IL10) affects fat cells and their ability to burn energy, which could help us find better ways to treat obesity and diabetes, so people can manage their weight and health more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11018584 on NIH RePORTER |
What this research studies
This research investigates the role of immune cells in the fat tissue environment and their impact on fat cell activation and energy expenditure. It focuses on a specific immune signaling molecule, interleukin-10 (IL10), which has been found to influence insulin sensitivity and glucose metabolism. By studying how IL10 affects fat cells and their thermogenic properties, the research aims to uncover mechanisms that could lead to improved treatments for conditions like obesity and diabetes. Patients may benefit from insights gained about how to enhance fat metabolism and manage weight-related health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who are dealing with insulin resistance or obesity-related health issues.
Not a fit: Patients who do not have issues related to insulin sensitivity or obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving insulin sensitivity and managing obesity-related conditions.
How similar studies have performed: Previous studies have shown promising results in understanding immune cell interactions with fat cells, suggesting that this approach could yield significant insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Rajbhandari, Prashant — Icahn School of Medicine at Mount Sinai
- Study coordinator: Rajbhandari, Prashant
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.