How high salt affects kidney function and blood pressure regulation
Official title: High salt-dependent regulation of the Na+/K+/2Cl- co-transporter (NKCC2) ubiquitination by E3-ubiquitin ligases in Thick Ascending Limb
Funded at Wayne State University · NIH-11138895 · Data updated 2026-11-12
This study is looking at how eating too much salt affects the kidneys' ability to control blood pressure, especially focusing on a protein that plays a key role, and it's particularly important for people with salt-sensitive high blood pressure, like some African Americans.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | June 12, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $115,500 |
| NIH project number | 1R03DK140261-01A1 |
| Project ID | NIH-11138895 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals, particularly African Americans, who experience salt-sensitive hypertension.
✕Less likely to help
Patients who do not have hypertension or who are not salt-sensitive may not benefit from this research.
What this research studies
This research investigates how high salt intake influences the kidneys' ability to manage blood pressure, particularly focusing on a specific protein called NKCC2. The study examines the role of E3-ubiquitin ligases in regulating NKCC2's function and how this process may differ in individuals with salt-sensitive hypertension. By using animal models, the researchers aim to uncover the molecular mechanisms that lead to increased blood pressure in response to salt intake, especially in populations at higher risk, such as African Americans.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for hypertension, particularly for those who are salt-sensitive.
How similar studies have gone: Previous research has shown promising results in understanding the role of ubiquitination in blood pressure regulation, indicating that this approach may yield valuable insights.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Ares-Sarmiento, Gustavo R — Wayne State University
- Study coordinator: Ares-Sarmiento, Gustavo R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.