How heme affects immune cell development and inflammation
Official title: Ligand-dependent regulation of the nuclear receptor REV-ERBa in TH17 cell development and inflammation
Funded at University of Florida · NIH-11005026 · Data updated 2026-11-12
This study is looking at how a natural molecule called heme affects certain immune cells that play a role in inflammation, especially in conditions like colitis, to help us understand how diet and the environment might influence gut health and improve treatment options for inflammatory diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | March 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $592,971 |
| NIH project number | 5R01DK135300-03 |
| Project ID | NIH-11005026 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from inflammatory bowel diseases, particularly those with colitis.
✕Less likely to help
Patients without inflammatory conditions or those not affected by TH17 cell-related inflammation may not benefit from this research.
What this research studies
This research investigates the role of heme, a natural molecule, in regulating immune cells known as TH17 cells, which are involved in inflammation and conditions like colitis. By understanding how heme influences the activity of a specific protein called REV-ERBa, the researchers aim to uncover the mechanisms that control inflammation in the gut. The study will explore both the sources of heme and its effects on immune responses, potentially leading to new insights into how dietary factors and environmental signals impact health. Patients may benefit from findings that could lead to better management of inflammatory diseases.
Why it matters
Potential benefit: If successful, this research could provide new strategies for treating inflammatory conditions like colitis.
How similar studies have gone: Previous research has shown promising results in understanding the role of ligands in immune regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Solt, Laura a — University of Florida
- Study coordinator: Solt, Laura a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.