How FOXO proteins influence stem cell behavior and development
Official title: Regulation of stem cell fate by FOXO and RNA binding proteins
Funded at Central Michigan University · NIH-11036488 · Data updated 2026-11-12
This study looks at how certain proteins help stem cells stay flexible and ready to become different types of cells, even when they're not actively dividing, using tiny worms as a model to learn more about how this works in all living things.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Central Michigan University NIH-funded |
| Lab location | 1 site (Mount Pleasant, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $60,571 |
| NIH project number | 3R15GM150082-01S1 |
| Project ID | NIH-11036488 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the mechanisms of stem cell behavior and potential applications in regenerative medicine.
✕Less likely to help
Patients with conditions unrelated to stem cell function or those not interested in research participation may not benefit from this research.
What this research studies
This research investigates the role of FOXO proteins in maintaining the multipotency of stem cells during periods when they are not dividing. Using the model organism C. elegans, the study focuses on understanding how these proteins regulate developmental pathways to control cell fate. By examining quiescent stem cells in a specific larval stage, the research aims to uncover the mechanisms that allow these cells to remain multipotent despite environmental stress. This innovative approach combines in vivo studies with insights from mammalian biology to enhance our understanding of stem cell regulation.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing stem cell therapies and improving regenerative medicine.
How similar studies have gone: While the specific approach using C. elegans is innovative, similar studies have shown success in understanding stem cell regulation in other model organisms.
Where this research is happening
-
Central Michigan University
Mount Pleasant, United States Active
Researchers
- Principal investigator: Karp, Xantha — Central Michigan University
- Study coordinator: Karp, Xantha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.