GATAD2 and NuRD’s role in FOXO/daf-16 control of stem cell fate
Official title: Investigating the role of GATAD2 and the NuRD complex in FOXO/daf-16 regulation of stem cell fate
Funded at Central Michigan University · NIH-11360918 · Data updated 2026-11-12
This grant studies how a key human-like stem-cell regulator interacts with chromatin factors to keep stem cells multipotent, using a worm model to illuminate potential human biology.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Central Michigan University NIH-funded |
| Lab location | 1 site (Mount Pleasant, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $531,680 |
| NIH project number | 2R15GM150082-02 |
| Project ID | NIH-11360918 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to direct patient participation in this project; modeled on human-relevant stem cell biology, with potential future translation.
✕Less likely to help
No direct patient involvement in this grant.
What this research studies
The project uses Caenorhabditis elegans to explore how FOXO/daf-16 and the NuRD complex influence stem cell multipotency during quiescence. By manipulating GATAD2 and NuRD components, researchers aim to map how developmental pathways control cell fate in a living organism. The work will examine single-cell changes in seam cells to understand how multipotency is maintained and how adult differentiation is guided. Findings could reveal conserved mechanisms relevant to human stem cell biology and aging.
Why it matters
Potential benefit: Understanding these pathways could inform strategies to preserve or restore stem cell function in humans.
How similar studies have gone: Previous work in C. elegans supports the feasibility of dissecting FOXO-related pathways; translation to humans remains to be demonstrated.
Where this research is happening
-
Central Michigan University
Mount Pleasant, United States Active
Researchers
- Principal investigator: Karp, Xantha — Central Michigan University
- Study coordinator: Karp, Xantha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.