How extreme heat and cold affect aging with Alzheimer’s and related dementias
Official title: The confluence of extreme heat and cold on aging and longevity
Funded at Harvard Medical School · NIH-11418111 · Data updated 2026-11-12
A study exploring how very hot or very cold weather might impact health and daily living for people aged 65 and older who have Alzheimer’s disease or related dementias.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $747,248 |
| NIH project number | 5R01AG074372-03 |
| Project ID | NIH-11418111 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults (65+) living with Alzheimer’s disease or related dementias who are experiencing or at risk from extreme temperature exposure.
✕Less likely to help
Individuals without dementia or those under 65 will not be the primary focus of this study.
What this research studies
This project from Harvard Medical School looks at how extreme temperatures could affect older adults living with AD/ADRD, a group already vulnerable to health problems. The researchers plan to connect patterns of extreme temperature with health outcomes like hospitalizations and care needs, focusing on mechanisms that might be involved in these populations. The work may involve analyzing health records, weather data, and possibly patient observations to understand how temperature shifts influence aging and dementia symptoms. By clarifying these connections, the study aims to inform better protection strategies and health planning for older adults during heatwaves and cold snaps.
Why it matters
Potential benefit: If successful, findings could guide public health recommendations and home-care practices to reduce weather-related risks for older adults with dementia.
How similar studies have gone: Previous research suggests temperature extremes impact health in older adults, but this study seeks to clarify pathways specifically for those with AD/ADRD.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Patel, Chirag J. — Harvard Medical School
- Study coordinator: Patel, Chirag J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.