NIH-funded research R01 grant

How extreme heat and cold affect aging with Alzheimer’s and related dementias

Official title: The confluence of extreme heat and cold on aging and longevity

Funded at Harvard Medical School · NIH-11418111 · Data updated 2026-11-12

A study exploring how very hot or very cold weather might impact health and daily living for people aged 65 and older who have Alzheimer’s disease or related dementias.

More Aging research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionHarvard Medical School
NIH-funded
Lab location1 site (Boston, United States)
Project startJune 1, 2022
Project endMay 31, 2027
Funding year2026
Award (this year)$747,248
NIH project number5R01AG074372-03
Project IDNIH-11418111 on NIH RePORTER

Who could benefit from this research

Could help

Older adults (65+) living with Alzheimer’s disease or related dementias who are experiencing or at risk from extreme temperature exposure.

Less likely to help

Individuals without dementia or those under 65 will not be the primary focus of this study.

What this research studies

This project from Harvard Medical School looks at how extreme temperatures could affect older adults living with AD/ADRD, a group already vulnerable to health problems. The researchers plan to connect patterns of extreme temperature with health outcomes like hospitalizations and care needs, focusing on mechanisms that might be involved in these populations. The work may involve analyzing health records, weather data, and possibly patient observations to understand how temperature shifts influence aging and dementia symptoms. By clarifying these connections, the study aims to inform better protection strategies and health planning for older adults during heatwaves and cold snaps.

Why it matters

Potential benefit: If successful, findings could guide public health recommendations and home-care practices to reduce weather-related risks for older adults with dementia.

How similar studies have gone: Previous research suggests temperature extremes impact health in older adults, but this study seeks to clarify pathways specifically for those with AD/ADRD.

Where this research is happening

  • Harvard Medical School
    Boston, United States
    Active

Researchers

  • Principal investigator: Patel, Chirag J. — Harvard Medical School
  • Study coordinator: Patel, Chirag J.

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.