How environmental chemicals affect RNA modifications in developing embryos
Role of m6A RNA modifications in AHR-mediated developmental toxicity
This study looks at how certain environmental chemicals, especially dioxins, might change a specific part of RNA in developing fish embryos, which could help us understand how these chemicals might affect growth and development in animals, including humans.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Woods Hole Oceanographic Institution NIH-funded |
| Lab location | 1 site (Woods Hole, United States) |
| Project ID | NIH-10647294 on NIH RePORTER |
What this research studies
This research investigates how exposure to environmental chemicals, particularly dioxins, impacts the modification of RNA in developing vertebrate embryos. The study focuses on a specific RNA modification known as m6A, which plays a crucial role in gene expression and various physiological processes. By examining the effects of different dioxin-like compounds on RNA methylation patterns, the researchers aim to understand the potential developmental toxicity associated with these exposures. The research utilizes zebrafish as a model organism to explore these effects in a controlled environment.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals concerned about the effects of environmental toxins on reproductive health and embryonic development.
Not a fit: Patients who are not affected by environmental toxins or who are not in the reproductive age group may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of how environmental toxins affect embryonic development and potentially inform strategies to mitigate these risks.
How similar studies have performed: Previous research has shown that environmental exposures can significantly alter gene expression and RNA modifications, suggesting that this approach may yield valuable insights.
Where this research is happening
Woods Hole, United States
- Woods Hole Oceanographic Institution — Woods Hole, United States (Active)
Researchers
- Principal investigator: Aluru, Neelakanteswar — Woods Hole Oceanographic Institution
- Study coordinator: Aluru, Neelakanteswar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.