How circadian rhythms affect immune responses after a stroke
Official title: Circadian Control of Brain-peripheral Immune Response After Stroke
Funded at Massachusetts General Hospital · NIH-10893595 · Data updated 2026-11-12
This study is looking at how our body's internal clock and age affect the immune system's response after a stroke, and it's designed to help improve recovery for stroke patients by understanding how the brain talks to important immune system nodes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $459,035 |
| NIH project number | 5R01NS129654-02 |
| Project ID | NIH-10893595 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a stroke, particularly older adults whose immune responses may be affected by aging.
✕Less likely to help
Patients who have not had a stroke or those with conditions that severely compromise their immune system may not benefit from this research.
What this research studies
This research investigates the relationship between circadian rhythms, aging, and the immune response following a stroke. It focuses on how the brain communicates with cervical lymph nodes, which play a crucial role in the immune system. By studying this signaling pathway, the researchers aim to understand how the timing of a stroke and the age of the patient can influence recovery and immune response. The project utilizes animal models to explore these interactions and their implications for stroke treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for stroke patients by optimizing timing and interventions based on circadian rhythms.
How similar studies have gone: Previous studies have shown promising results in understanding the role of circadian rhythms in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Esposito, Elga — Massachusetts General Hospital
- Study coordinator: Esposito, Elga
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.