How changes in cell structure contribute to aging.
Official title: Chromatin architecture disruption and the vicious cycle of aging.
Funded at Boston University Medical Campus · NIH-10901040 · Data updated 2026-11-12
This study is looking at how changes in the way our cell nuclei are organized might be connected to aging and health problems, with the hope that understanding these changes can help develop new treatments for age-related issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $412,500 |
| NIH project number | 1R56AG082796-01 |
| Project ID | NIH-10901040 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing premature aging conditions or age-related diseases.
✕Less likely to help
Patients with no signs of aging or age-related conditions may not receive any benefit from this research.
What this research studies
This research investigates how disruptions in the structure of cell nuclei, known as chromatin architecture, are linked to the aging process. It focuses on the activation of specific genes that can lead to chronic inflammation and other age-related issues. By studying both human cells and mouse models, the research aims to understand the mechanisms behind these changes and their impact on health. Patients may benefit from insights that could lead to new treatments for age-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related diseases by targeting the underlying mechanisms of aging.
How similar studies have gone: Previous research has shown promising results in understanding the role of chromatin architecture in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Beck, Samuel — Boston University Medical Campus
- Study coordinator: Beck, Samuel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.