How Cells Move and Communicate
Actin gating of crosstalk between Rho GTPases in cell migration
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11105845
This project aims to understand how cells move and communicate, which is important for our immune system, development, and how cancer spreads.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11105845 on ClinicalTrials.gov |
What this research studies
Our bodies rely on cells moving correctly for many important functions, like fighting off infections or healing wounds. This movement requires cells to know which way to go and how to organize themselves. We are looking closely at tiny switches inside cells, called Rho GTPases, that help direct this movement and communication. By understanding how these switches work together and how they are controlled, we hope to find new ways to address problems like inflammation or the spread of cancer. We are using special tools to watch these processes in live cells.
Who could benefit from this research
Good fit: This foundational research is relevant for patients with conditions like atherosclerotic cardiovascular disease, autoimmune diseases, and cancer, as it explores basic cell processes involved in these illnesses.
Not a fit: Patients seeking immediate new treatments or direct clinical trial participation would not directly benefit from this early-stage basic science.
Why it matters
Potential benefit: If successful, this work could lead to new ways to treat conditions involving inflammation, autoimmune diseases, and the spread of cancer by targeting how cells move.
How similar studies have performed: This project builds on existing knowledge of cell signaling but uses novel molecular tools to gain a deeper, more detailed understanding of these complex cellular interactions.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COLLINS, SEAN RYAN — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: COLLINS, SEAN RYAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease, Autoimmune Diseases