How blood stem cells develop into red blood cells
Official title: Mechanisms that regulate erythroid differentiation of hematopoietic stem cells
Funded at Baylor College of Medicine · NIH-11029945 · Data updated 2026-11-12
This study is looking at how special blood-making cells in your body react when you're dealing with anemia, to help find better ways to treat this condition and improve blood health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $86,400 |
| NIH project number | 3R01HL165145-03S1 |
| Project ID | NIH-11029945 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from anemia or conditions that affect red blood cell production.
✕Less likely to help
Patients with stable blood cell counts and no history of anemia may not benefit from this research.
What this research studies
This research investigates how hematopoietic stem cells (HSCs), which are responsible for producing blood cells, respond to conditions that cause anemia. The study focuses on understanding the signals and mechanisms that enhance the differentiation of these stem cells into red blood cells during stress situations, such as hemolytic anemia. By using advanced lineage tracing models, researchers aim to identify the specific progenitor cell populations and the role of iron in promoting this process. The findings could lead to new strategies for treating anemia and improving regenerative medicine.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for anemia by enhancing the body's ability to produce red blood cells.
How similar studies have gone: Previous research has shown promising results in understanding stem cell differentiation, making this approach both relevant and potentially impactful.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Nakada, Daisuke — Baylor College of Medicine
- Study coordinator: Nakada, Daisuke
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.