How antibody formulations behave in subcutaneous injections
Official title: SAXS-Guided Coarse-Grained Model Development to Elucidate Antibody-Antibody Interactions for Subcutaneous Drug Delivery
Funded at The Trustees of the Stevens Institute of Technology · NIH-11453934 · Data updated 2026-11-12
A project aims to build computer models that link antibody sequences to how they move and clump in high-concentration solutions used for subcutaneous shots.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | The Trustees of the Stevens Institute of Technology NIH-funded |
| Lab location | 1 site (Hoboken, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $192,765 |
| NIH project number | 1R21AI196601-01A1 |
| Project ID | NIH-11453934 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who receive high-concentration antibody therapies via subcutaneous injections could benefit from improved formulations.
✕Less likely to help
If a specific antibody formulation is not suitable for a patient’s regimen, they may not experience direct benefit from this project.
What this research studies
If funded, researchers will combine experimental data from small-angle X-ray scattering with measurements of viscosity and aggregation to train a machine learning–based coarse-grained model. The goal is to predict how different antibody sequences will behave in formulations that are injected under the skin, helping design better, more injectable drugs. This patient-facing research could lead to safer, more convenient antibody therapies with fewer needle-related issues.
Why it matters
Potential benefit: Potentially smoother, more reliable subcutaneous antibody injections for patients.
How similar studies have gone: Previous work has used computational models to study protein interactions, but this project aims to improve predictive accuracy with ML-guided parameters and SAXS data.
Where this research is happening
-
The Trustees of the Stevens Institute of Technology
Hoboken, United States Active
Researchers
- Principal investigator: Lai, Pin-Kuang — The Trustees of the Stevens Institute of Technology
- Study coordinator: Lai, Pin-Kuang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.