How aging cells affect blood vessel growth and tissue repair
Official title: Mechanism of endothelial senescence in tissue regeneration and repair
Funded at Medical College of Wisconsin · NIH-11459333 · Data updated 2026-11-12
This grant studies how aging cells influence the growth of tiny blood vessels to help healing in tissues, with a focus on improving therapies for age-related diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $618,354 |
| NIH project number | 1R01AG095980-01A1 |
| Project ID | NIH-11459333 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with age-related tissue repair challenges or diseases where angiogenesis is impaired, who could participate through future translational studies or related patient-derived samples.
✕Less likely to help
Patients with conditions unrelated to aging or angiogenesis may not directly benefit from this basic mechanistic study.
What this research studies
As we age, our tissues don’t form new blood vessels as well, which can hamper healing. The researchers will use mouse wound and lung models, plus human organoid systems, to understand how endothelial cell aging affects angiogenesis during repair. They will explore the role of adiponectin, a molecule that may help prevent cell aging and promote vessel growth, and look at how aging changes signaling pathways like Wnt/LRP5 in blood vessel formation. The goal is to identify targets that could enhance tissue regeneration in older people. This work could lay groundwork for therapies that improve healing in age-related conditions.
Why it matters
Potential benefit: If successful, the findings could lead to therapies that boost tissue repair and regeneration in older adults by enhancing blood vessel formation.
How similar studies have gone: Prior studies show that modulating senescence and adiponectin signaling can influence blood vessel growth, suggesting potential for translation.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Mammoto, Akiko — Medical College of Wisconsin
- Study coordinator: Mammoto, Akiko
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.